I just created this chart to better understand how PTN moved on the big spike recently. Seems like it didn't take much, just a Yahoo article after the positive dry eye news and then a few YouTube videos.
Here are the links to the article and videos:
12/22/2020 Michael Marcus - TipRanks tipranks.com/news/article/these-2-penny-stocks-are-poised-for-a-massive-rally-say-analysts
12/22/2020 JT Wealth - YouTube youtube.com/watch?v=H1mP74IQGng&t=20s
12/25/2020 Kenan Grace - YouTube youtube.com/watch?v=wlt93RTyN4M
12/27/2020 Kenan Grace - YouTube youtube.com/watch?v=5zpn10RupY8&t=13s
1/18/2021 Market Gains - Youtube youtube.com/watch?v=ufy7AaQF0Ak&t=51s
1/22/2021 Kenan Grace - YouTube youtube.com/watch?v=LNEAXrMQTyI&t=185s
3/25/2021 Kenan Grace - YouTube youtube.com/watch?v=B7YZDIALwF8&t=153s
Potential Upcoming Catalysts
Eye Preclinical - Next Anterior Indication
Vyleesi - Korea PK
Vyleesi - China PK
PL9643 - PH2/3 Initiate
Diabetic Retinopathy - File IND
PL8177 IBD - PH2 Initiate
Vyleesi - Multiple ROW deals
Vyleesi - NA deal
I would watch for the recent dry eye news or one of the above catalysts to result in another spike after new articles and videos are published.