Considering the institute and big whales are conservative, they will not take long position when CME opens.
They will try to get most of the coins' price to buy at a relatively cheap price. To summarize, they will take Short position.
Once institute and big players started to get short position, minor people will panic and sell their coins.
This over-sell will cause demand to withdraw on Bitfinex, which does not have enough fiat supply for withdrawals, and make BitFinex bankrupted. This will be a good material for a long-going down of the Price https://www.tradingview.com/x/QnkpbH1F/